Significance of human muscle fibers as research subject

The relevance to the study of human performance, ageing, and disease;

Relatively slow kinetic properties make their study easier than that of muscle fibers obtained from smaller animal species;

As large fibers, they are stable in vitro after permeabilization, and maintain a good sarcomere pattern, even during repeated, long, maximum contractions;

He, ZH., ATP consumption and efficiency of human single muscle fibers with different myosin isoform composition. Biophys J, 2000 Aug;79(2):945-61.

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